Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging
نویسندگان
چکیده
منابع مشابه
amyloid precursor protein processing in alzheimer’s disease
how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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Understanding of trafficking, processing, and degradation mechanisms of amyloid precursor protein (APP) is important because APP can be processed to produce β-amyloid (Aβ), a key pathogenic molecule in Alzheimer's disease (AD). Here, we found that APP contains KFERQ motif at its C-terminus, a consensus sequence for chaperone-mediated autophagy (CMA) or microautophagy which are another types of ...
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The possibility to understand the causes and treat the symptoms of Alzheimer's disease patients is still a great challenge. The triggering events leading to the selective neurodegeneration observed in Alzheimer's brains are not completely understood. This lack of understanding of the pathophysiological processes posses an important theoretical challenge for the rational design of pharmacologica...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m505625200